Key Publications

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Mansfeld J, Urban N, Priebe S, Groth M, Frahm C, Hartmann N, Gebauer J, Ravichandran M, Dommaschk A, Schmeisser S, Kuhlow D, Monajembashi S, Bremer-Streck S, Hemmerich P, Kiehntopf M, Zamboni N, Englert C, Guthke R, Kaleta C, Platzer M, Sühnel J, Witte O, Zarse K, Ristow M: Branched-chain amino acid catabolism is a conserved regulator of physiological ageing. Nature Commun 6:10043 (2015)

Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, Merry TL, Dubuis S, Laube B, Pfeiffer AF, Schulz TJ, Guthke R, Platzer M, Zamboni N, Zarse K, Ristow M: D-Glucosamine supplementation extends lifespan of nematodes and of ageing mice. Nature Commun, 5, e3563 (2014)

Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M: Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nature Chem Biol, 9, 693-700 (2013)

Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JM, Guthke R, Platzer M, Zarse K, Ristow M: Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell, 12, 508-17 (2013)

Zarse K, Schmeisser S, Groth M, Priebe S, Beuster G, Kuhlow D, Guthke R, Platzer M, Kahn CR, Ristow M: Impaired insulin-/IGF1-signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab, 15, 451-465 (2012)

Ristow M, Zarse K, Oberbach A, Kiehntopf M, Birringer M, Stumvoll M, Kahn CR, Blüher M: Antioxidants prevent anti-diabetic and health-promoting effects of physical exercise in humans, Proc Natl Acad Sci USA, 106: 8665-70 (2009)

Schulz TJ, Voigt A, Zarse K, Birringer M, Ristow M: Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial metabolism and increasing oxidative stress, Cell Metab, 6: 280-293 (2007)

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