Key Publications
Ravichandran M, Priebe S, Rozarov L, Groth M, Laube B, Guthke R, Platzer M, Zarse K, Ristow M: Impairing L-threonine catabolism promotes healthspan through methylglyoxal-mediated proteohormesis. Cell Metab, 27, 914-925 (2018) external pagehttps://doi.org/10.1016/j.cmet.2018.02.004call_made
Hirose M, Schilf P, Gupta Y, Wright M, Jöhren O, Wagner A, Sina C, Ziegler A, Ristow M, Ibrahim SM: Lifespan effects of mitochondrial mutations. Nature 540, E13-E14 (2016) external pagewww.nature.com/nature/journal/v540/n7633/full/nature20778.htmlcall_made
Mansfeld J, Urban N, Priebe S, Groth M, Frahm C, Hartmann N, Gebauer J, Ravichandran M, Dommaschk A, Schmeisser S, Kuhlow D, Monajembashi S, Bremer-Streck S, Hemmerich P, Kiehntopf M, Zamboni N, Englert C, Guthke R, Kaleta C, Platzer M, Sühnel J, Witte O, Zarse K, Ristow M: Branched-chain amino acid catabolism is a conserved regulator of physiological ageing. Nature Commun 6:10043 (2015) Downloadwww.nature.com/articles/ncomms10043vertical_align_bottom
Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, Merry TL, Dubuis S, Laube B, Pfeiffer AF, Schulz TJ, Guthke R, Platzer M, Zamboni N, Zarse K, Ristow M: D-Glucosamine supplementation extends lifespan of nematodes and of ageing mice. Nature Commun, 5, e3563 (2014) Downloadwww.nature.com/doifinder/10.1038/ncomms4563vertical_align_bottom
Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M: Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nature Chem Biol, 9, 693-700 (2013) Downloadwww.nature.com/doifinder/10.1038/nchembio.1352vertical_align_bottom
Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JM, Guthke R, Platzer M, Zarse K, Ristow M: Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell, 12, 508-17 (2013) Downloadwww.onlinelibrary.wiley.com/doi/10.1111/acel.12076/abstractvertical_align_bottom
Zarse K, Schmeisser S, Groth M, Priebe S, Beuster G, Kuhlow D, Guthke R, Platzer M, Kahn CR, Ristow M: Impaired insulin-/IGF1-signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab, 15, 451-465 (2012) Downloadwww.sciencedirect.com/science/article/pii/S1550413112000940vertical_align_bottom
Ristow M, Zarse K, Oberbach A, Kiehntopf M, Birringer M, Stumvoll M, Kahn CR, Blüher M: Antioxidants prevent anti-diabetic and health-promoting effects of physical exercise in humans, Proc Natl Acad Sci USA, 106: 8665-70 (2009) Downloadwww.pnas.org/content/106/21/8665.longvertical_align_bottom
Schulz TJ, Voigt A, Zarse K, Birringer M, Ristow M: Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial metabolism and increasing oxidative stress, Cell Metab, 6: 280-293 (2007) Downloadwww.sciencedirect.com/science/article/pii/S1550413107002562vertical_align_bottom