Key Publications

Ravichandran M, Priebe S, Rozarov L, Groth M, Laube B, Guthke R, Platzer M, Zarse K, Ristow M: Impairing L-threonine catabolism promotes healthspan through methylglyoxal-mediated proteohormesis. Cell Metab, 27, 914-925 (2018) external pagehttps://doi.org/10.1016/j.cmet.2018.02.004

Hirose M, Schilf P, Gupta Y, Wright M, Jöhren O, Wagner A, Sina C, Ziegler A, Ristow M, Ibrahim SM: Lifespan effects of mitochondrial mutations. Nature 540, E13-E14 (2016) external pagewww.nature.com/nature/journal/v540/n7633/full/nature20778.html

Mansfeld J, Urban N, Priebe S, Groth M, Frahm C, Hartmann N, Gebauer J, Ravichandran M, Dommaschk A, Schmeisser S, Kuhlow D, Monajembashi S, Bremer-Streck S, Hemmerich P, Kiehntopf M, Zamboni N, Englert C, Guthke R, Kaleta C, Platzer M, Sühnel J, Witte O, Zarse K, Ristow M: Branched-chain amino acid catabolism is a conserved regulator of physiological ageing. Nature Commun 6:10043 (2015) Downloadwww.nature.com/articles/ncomms10043

Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, Merry TL, Dubuis S, Laube B, Pfeiffer AF, Schulz TJ, Guthke R, Platzer M, Zamboni N, Zarse K, Ristow M: D-Glucosamine supplementation extends lifespan of nematodes and of ageing mice. Nature Commun, 5, e3563 (2014) Downloadwww.nature.com/doifinder/10.1038/ncomms4563

Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M: Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nature Chem Biol, 9, 693-700 (2013) Downloadwww.nature.com/doifinder/10.1038/nchembio.1352

Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JM, Guthke R, Platzer M, Zarse K, Ristow M: Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell, 12, 508-17 (2013) Downloadwww.onlinelibrary.wiley.com/doi/10.1111/acel.12076/abstract

Zarse K, Schmeisser S, Groth M, Priebe S, Beuster G, Kuhlow D, Guthke R, Platzer M, Kahn CR, Ristow M: Impaired insulin-/IGF1-signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab, 15, 451-465 (2012) Downloadwww.sciencedirect.com/science/article/pii/S1550413112000940

Ristow M, Zarse K, Oberbach A, Kiehntopf M, Birringer M, Stumvoll M, Kahn CR, Blüher M: Antioxidants prevent anti-diabetic and health-promoting effects of physical exercise in humans, Proc Natl Acad Sci USA, 106: 8665-70 (2009) Downloadwww.pnas.org/content/106/21/8665.long

Schulz TJ, Voigt A, Zarse K, Birringer M, Ristow M: Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial metabolism and increasing oxidative stress, Cell Metab, 6: 280-293 (2007) Downloadwww.sciencedirect.com/science/article/pii/S1550413107002562