Energy Metabolism Laboratory


Key Publications

Ristow M Nature Medicine, 20, 709-711 (2014) »

Weimer S, Priebs J, et al. Nature Commun, 5, e3563 (2014) »

Schmeisser K, Mansfeld J, et al., Nat Chem Biol, 9, 693-700 (2013) »

Zarse K, et al., Cell Metab, 15, 451-465 (2012) »

Ristow M, et al., Proc Natl Acad Sci USA, 106:8865-70 (2009) »

Schulz TJ, et al., Cell Metab, 6: 280-293 (2007) »

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Welcome to the Energy Metabolism Lab. Being located at the ETH Zurich since January 2013, we are pursuing our research on the biochemical and molecular basis of longevity regulation to provide novel therapeutic options to prevent and cure age-related diseases like obesity, diabetes and cancer.

We are interested in the biochemical and molecular basis of longevity — in particular the role played by mitochondria in lifespan regulation. Contrary to the widely reiterated Free Radical Theory of Aging, we have repeatedly shown that the health-promoting effects associated with low caloric intake, physical exercise and other lifespan-extending interventions may be due to increased formation of Reactive Oxygen Species (ROS) within the mitochondria, causing a vaccination-like adaptive response that culminates in increased stress resistance and extended longevity, a process a. k. a. mitochondrial hormesis or mitohormesis. We work with the roundworm C. elegans and mammalian model organisms, as well as occasionally in humans.

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